EFI-EST: A free tool for visualizing sequence–function relationships

As genome sequencing has become routine, the rate of increase in the number of uncharacterized/unknown or hypothetical proteins in the sequence databases has exceeded the ability to assign their biological functions. Addressing this challenge requires tools to focus experimental efforts. A sequence similarity network (SSN) is an example of such a tool—it enables facile visualization of sequence-function relationships in protein families, thereby focusing sequence-based functional annotation efforts.

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