Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress [Signal Transduction]

Posted on Dec 9th, 2020 - By Sandip M Swain, Rodger A Liddle

Determinants of replication protein A subunit interactions revealed using a phosphomimetic peptide [Molecular Biophysics]

Posted on Oct 30th, 2020 - By Sungjin Lee, Jeongbeen Heo, Chin-Ju Park

Glycans function as a Golgi export signal to promote the constitutive exocytic trafficking [Membrane Biology]

Posted on Aug 21st, 2020 - By Xiuping Sun, Hieng Chiong Tie, Bing Chen, Lei Lu

Catastrophic actin filament bursting by cofilin, Aip1, and coronin [Cell Biology]

Survivin in breast cancer-derived exosomes activates fibroblasts by upregulating SOD1, whose feedback promotes cancer proliferation and metastasis [Molecular Bases of Disease]

Evidence that polyphenols do not inhibit the phospholipid scramblase TMEM16F [Molecular Biophysics]

H2S and reactive sulfur signaling at the host bacterial pathogen interface [Gene Regulation]

Posted on Jul 22nd, 2020 - By Brenna J.C. Walsh, David P. Giedroc

Ubiquitination of interleukin-1{alpha} is associated with increased pro-inflammatory polarization of murine macrophages deficient in the E3 ligase ITCH [Cell Biology]

Viperin: an ancient radical-SAM enzyme finds its place in modern cellular metabolism and innate immunity [Immunology]

Posted on Jun 16th, 2020 - By Soumi Ghosh, E. Neil G. Marsh

Roles of active site residues in catalysis, substrate binding, cooperativity and the reaction mechanism of the quinoprotein glycine oxidase [Enzymology]

The single CCA-adding enzyme of T. brucei has distinct functions in the cytosol and in mitochondria [RNA]

Posted on Mar 31st, 2020 - By Shikha Shikha, Andre Schneider

Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2 [Enzymology]

Posted on Mar 6th, 2020 - By Suparno Nandi, Mishtu Dey

HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane [Microbiology]

On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability [DNA and Chromosomes]

Posted on Feb 14th, 2020 - By Alexandra N. Khristich, Sergei M. Mirkin

Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody [Protein Synthesis and Degradation]

The manifold roles of microbial ribosomal peptide-based natural products in physiology and ecology [Metabolism]

Posted on Nov 29th, 2019 - By Yanyan Li, Sylvie REBUFFAT

Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules [Protein Synthesis and Degradation]

Influenza A virus-induced host caspase and viral PA-X antagonise the antiviral host factor, histone deacetylase 4 [Microbiology]

Posted on Nov 22nd, 2019 - By Henry D Galvin, Matloob Husain

A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration [Cell Biology]

The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription [Microbiology]

Biological, chemical, and biochemical strategies for modifying glycopeptide antibiotics [Enzymology]

Posted on Oct 31st, 2019 - By Edward Marschall, Max J. Cryle, Julien Tailhades

Resolving the topological enigma in Ca2+-signaling by cyclic ADP-ribose and NAADP [Signal Transduction]

Posted on Oct 31st, 2019 - By Hon Cheung Lee, Yong Juan Zhao

Detection, identification and quantification of oxidative protein modifications [Protein Synthesis and Degradation]

Posted on Oct 31st, 2019 - By Clare L Hawkins, Michael J Davies

The scavenger receptor SCARA1(CD204) recognizes dead cells through spectrin [Immunology]

Intestinal breast cancer resistance protein (BCRP) requires Janus kinase 3 activity for drug efflux and barrier functions in obesity [Signal Transduction]

The trypanosome-specific proteins FPRC and CIF4 regulate cytokinesis initiation by recruiting CIF1 to the cytokinesis initiation site [Microbiology]

Phagocytosis mediated by scavenger receptor class BI promotes macrophage transition during skeletal muscle regeneration [Immunology]

Genetically encoded fluorescent biosensors illuminate kinase signaling in cancer [Cell Biology]

Posted on Aug 21st, 2019 - By Wei Lin, Sohum Mehta, Jin Zhang

The N-terminal domain of an archaeal multidrug and toxin extrusion (MATE) transporter mediates proton coupling required for prokaryotic drug resistance [Molecular Biophysics]

Fast photochemical oxidation of proteins(FPOP): A powerful mass spectrometry based structural proteomics tool [Methods and Resources]

DNA duplex recognition activates Exo1 nuclease activity [DNA and Chromosomes]

Posted on Jun 10th, 2019 - By Yuxi Li, Jiangchuan Shen, Hengyao Niu

Unraveling the role of the transcriptional regulator VirS in low pH-induced responses of Mycobacterium tuberculosis and identification of VirS inhibitors [Microbiology]

Face-time with TAR: Portraits of an HIV-1 RNA with diverse modes of effector recognition relevant for drug discovery [RNA]

Phosphorylation of Tyr950 in the proteasome scaffolding protein RPN2 modulates its interaction with theubiquitin receptor RPN13 [Protein Synthesis and Degradation]

The FtsK-like motor TraB is a DNA-dependent ATPase that forms higher-order assemblies [Microbiology]

15-Deoxy-{Delta}12,14-prostaglandin J2 promotes phosphorylation of eukaryotic initiation factor 2{alpha} and activates the integrated stress response [Neurobiology]

Posted on Feb 5th, 2019 - By Devin Tauber, Roy Parker

A stable tetramer is not the only oligomeric state that mitochondrial single-stranded DNA binding proteins can adopt. [DNA and Chromosomes]

Post-transcriptional regulation of the Pseudomonas aeruginosa heme assimilation system (Has) fine-tunes extracellular heme sensing [Gene Regulation]

Friend or foe — post-translational modifications as regulators of phase separation and RNP granule dynamics [Molecular Bases of Disease]

Posted on Dec 26th, 2018 - By Mario Hofweber, Dorothee Dormann

Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex [Protein Synthesis and Degradation]

Posted on Dec 17th, 2018 - By Janakiram R Vangala, Senthil K Radhakrishnan

Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design [Molecular Bases of Disease]

Posted on Nov 13th, 2018 - By Simone Brixius-Anderko, Emily E. Scott

Transglutaminase inhibition stimulates hematopoiesis and reduces aggressive behavior of crayfish, Pacifastacus leniusculus [Cell Biology]

Exploring the quinone/inhibitor-binding pocket in mitochondrial respiratory complex I by chemical biology approaches [Enzymology]

Small heat shock proteins: Simplicity meets complexity [Cell Biology]

Mechanistic basis for the evolution of chalcone synthase catalytic cysteine reactivity in land plants [Plant Biology]

RNF144A Sustains EGFR Signaling to Promote EGF-Dependent Cell Proliferation [Protein Synthesis and Degradation]

Posted on Aug 31st, 2018 - By Shiuh-Rong Ho, Weei-Chin Lin

Identification of a Kdn biosynthesis pathway in the haptophyte Prymnesium parvum suggests widespread sialic acid biosynthesis among microalgae [Enzymology]

Posted on Aug 31st, 2018 - By Ben A Wagstaff, Martin Rejzek, Robert A. Field

p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation [Cell Biology]

Posted on Aug 24th, 2018 - By Rongde Qiu, Jun Zhang, Xin Xiang

Are N- and C-terminally Truncated A{beta} species key pathological triggers in Alzheimer’s disease? [Neurobiology]

Posted on Aug 24th, 2018 - By Julie Dunys, Audrey Valverde, Frederic Checler

Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G1 arrest independent of DRD2 [Signal Transduction]

Posted on Aug 21st, 2018 - By Matthew Tegowski, Cheng Fan, Albert S. Baldwin

Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses [Signal Transduction]

The Saccharomyces cerevisiae Hrq1 and Pif1 DNA helicases synergistically modulate telomerase activity in vitro [Enzymology]

The molecular language of membraneless organelles [Cell Biology]

Posted on Jul 25th, 2018 - By Edward Gomes, James Shorter

The RNA-binding complex ESCRT-II in Xenopus laevis eggs recognizes purine-rich sequences through its subunit Vps25 [Cell Biology]

Posted on Jun 14th, 2018 - By Amy B Emerman, Michael Blower

ER-resident protein 46 (ERp46) triggers the mannose-trimming activity of ER degradation-enhancing {alpha}-mannosidase-like protein 3 (EDEM3) [Protein Synthesis and Degradation]

Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity [RNA]

Posted on May 21st, 2018 - By Wei Cui, Ryoma Yoneda, Naomi Ueda, Riki Kurokawa

The ribosome: A hot spot for the identification of new types of protein methyltransferases [Protein Synthesis and Degradation]

Posted on May 9th, 2018 - By Steven G. Clarke

Lessons from my undergraduate research students [Computational Biology]

Posted on May 9th, 2018 - By Paul A Craig

NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation. [Neurobiology]

Posted on May 7th, 2018 - By Nicolas Paradis-Isler, Jannic Boehm

A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila [RNA]

Cytotoxic and mutagenic properties of minor-groove O2-alkylthymidine lesions in human cells [DNA and Chromosomes]

Effects of hypo O-GlcNAcylation on Drosophila development [Developmental Biology]

Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef [Microbiology]

Phospholipid Subcellular Localization and Dynamics [Membrane Biology]

Posted on Mar 27th, 2018 - By Yanbo Yang, Minhyoung Lee, Gregory D. Fairn

Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by {alpha}-amanitin [Protein Structure and Folding]

The major facilitator transporter Str3 is required for low-affinity heme acquisition in Schizosaccharomyces pombe [Microbiology]

Posted on Mar 16th, 2018 - By Vincent Normant, Thierry Mourer, Simon Labbe

Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I [Protein Synthesis and Degradation]

Posted on Feb 1st, 2018 - By Lei Lei, Joanna Bandola-Simon, Paul A. Roche

Leptin enhances hypothalamic LDHA-dependent glucose sensing to lower glucose production in high-fat fed rats. [Metabolism]

The cytochrome P450 24A1 interaction with adrenodoxin relies on multiple recognition sites that vary among species [Molecular Biophysics]

Posted on Jan 25th, 2018 - By D. Fernando Estrada

A Molecular Perspective of Mammalian Autophagosome Biogenesis [Membrane Biology]

Posted on Jan 25th, 2018 - By Thomas J. Mercer, Andrea Gubas, Sharon A. Tooze

Transcriptional and post-transcriptional regulation of autophagy in the yeast Saccharomyces cerevisiae [Cell Biology]

Posted on Jan 25th, 2018 - By Elizabeth Delorme-Axford, Daniel J. Klionsky

Toxoplasma gondii disrupts {beta}1 integrin signaling and focal adhesion formation during monocyte hypermotility [Immunology]

The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane [Membrane Biology]

Chaperone-mediated autophagy and endosomal microautophagy: joint by a chaperone [Metabolism]

Posted on Dec 15th, 2017 - By Kumsal A Tekirdag, Ana Maria Cuervo

Nonhomologous DNA End Joining for Repair of DNA Double-Strand Breaks [Protein Structure and Folding]

The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death [Cell Biology]

Posted on Dec 14th, 2017 - By Lang Yoo, Kwang Chul Chung

Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity [Immunology]

Posted on Dec 14th, 2017 - By Preeti Sharma, David M Kranz

The inducible microRNA-203 in fish represses the inflammatory responses to Gram-negative bacteria by targeting IL-1 receptor-associated kinase 4 [Gene Regulation]

Posted on Dec 14th, 2017 - By Tianjun Xu, Qing Chu, Junxia Cui, Xueyan Zhao

Structural and Functional Effects of Cytochrome b5 Interactions with Human Cytochrome P450 Enzymes [Enzymology]

Posted on Oct 27th, 2017 - By Aaron G. Bart, Emily E. Scott

Structural analyses of the bacterial primosomal protein DnaB reveal that it is a tetramer and forms a complex with a primosomal re-initiation protein [Protein Structure and Folding]

Efficient reduction of CO2 by the molybdenum-containing formate dehydrogenase from Cupriavidus necator (Ralstonia eutropha). [Molecular Biophysics]

Palmitoylation is a prerequisite for dimerization-dependent raftophilicity of rhodopsin [Membrane Biology]

Posted on Jul 26th, 2017 - By Keiji Seno, Fumio Hayashi

Iron Transport Proteins: Gateways of Cellular and Systemic Iron Homeostasis [Cell Biology]

Posted on Jun 16th, 2017 - By Mitchell D. Knutson

A ciliary opsin in the brain of a marine annelid zooplankton is UV-sensitive and the sensitivity is tuned by a single amino acid residue [Molecular Biophysics]

Endoplasmic Reticulum Stress-induced Degradation of DNAJB12 Stimulates BOK Accumulation and Primes Cancer Cells for Apoptosis [Cell Biology]

The sialate O-acetylesterase EstA from gut Bacteroidetes species enables sialidase-mediated cross-species foraging of 9-O-acetylated sialoglycans [Microbiology]

Posted on May 19th, 2017 - By Lloyd S Robinson, Warren G Lewis, Amanda L Lewis

Functional regions of the peroxin Pex19 necessary for peroxisome biogenesis [Membrane Biology]

H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductase [Enzymology]

Posted on May 16th, 2017 - By Aaron P Landry, David P Ballou, Ruma Banerjee

Reactive Oxygen Species Production Induced by Pore Opening in Cardiac Mitochondria: The Role of Complex II [Bioenergetics]

Disease-Associated Extracellular Loop Mutations in the Adhesion G Protein-Coupled Receptor G1 (ADGRG1; GPR56) Differentially Regulate Downstream Signaling [Molecular Bases of Disease]

Posted on Apr 19th, 2017 - By Ayush Kishore, Randy A. Hall

pH regulation in early endosomes and interferon-inducible transmembrane proteins control avian retrovirus fusion [Membrane Biology]

The RecJ2 Protein in the Thermophilic Archaeon Thermoplasma acidophilum Is a 3′ 5′ Exonuclease and Associates with a DNA Replication Complex [Microbiology]

Adjacent channelrhodopsin-2 residues within transmembranes 2 and 7 regulate cation selectivity and distribution of the two open states [Membrane Biology]

Posted on Mar 16th, 2017 - By Ryan Richards, Robert E. Dempski

Two alternative binding mechanisms connect the protein translocation Sec71/Sec72 complex with heat shock proteins [Protein Structure and Folding]

A New General Method for Simultaneous Fitting of Temperature- and Concentration-Dependence of Reaction Rates Yields Kinetic and Thermodynamic Parameters for HIV Reverse Transcriptase Specificity [DNA and Chromosomes]

Posted on Mar 2nd, 2017 - By An Li, Jessica L. Ziehr, Kenneth A. Johnson

Structural Basis for the Lesion-scanning Mechanism of the Bacterial MutY DNA Glycosylase [Enzymology]

Super-resolution visualization of caveolae deformation in response to osmotic stress [Signal Transduction]

Posted on Jan 17th, 2017 - By Lu Yang, Suzanne Scarlata

Autoinhibition of the Nuclease ARTEMIS is Mediated by a Physical Interaction between Its Catalytic and C-terminal Domains [Immunology]

RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis [Signal Transduction]

Posted on Dec 22nd, 2016 - By Sajad Mir, Weikang Cai, Douglas A. Andres

Molecular Identification of D-Ribulokinase in Budding Yeast and Mammals [Enzymology]