[ASAP] Uncoupling Amphipathicity and Hydrophobicity: Role of Charge Clustering in Membrane Interactions of Cationic Antimicrobial Peptides

Posted on Aug 22nd, 2021 - By Shelley He, Tracy A. Stone, and Charles M. Deber

[ASAP] Liquid–Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences

Posted on Jul 21st, 2021 - By Zhe Feng, Bowen Jia, and Mingjie Zhang

[ASAP] Correlated Motions in Structural Biology

Posted on Jul 21st, 2021 - By Da Xu, Steve P. Meisburger, and Nozomi Ando

[ASAP] Mechanism of Oxygen Evolution and Mn<sub>4</sub>CaO<sub>5</sub> Cluster Restoration in the Natural Water-Oxidizing Catalyst

[ASAP] Novel Mechanisms of Molecular Glue-Induced Protein Degradation

Posted on Jul 18th, 2021 - By Shanique Alabi

[ASAP] Chance Favors the Perplexed Mind: The Critical Role of Mechanistic Biochemistry in Drug Discovery

Posted on Jul 13th, 2021 - By Robert A. Copeland

[ASAP] Partial Consensus Design and Enhancement of Protein Function by Secondary-Structure-Guided Consensus Mutations

[ASAP] Origins of Ca<sup>2+</sup> Imaging with Fluorescent Indicators

Posted on Jul 11th, 2021 - By Xinqi Zhou, Kayla J. Belavek, and Evan W. Miller

[ASAP] Protein Engineering in the Design of Protein–Protein Interactions: SARS-CoV-2 Inhibitors as a Test Case

Posted on Jun 30th, 2021 - By Jiří Zahradník and Gideon Schreiber

[ASAP] Oligomerization of THAP9 Transposase via Amino-Terminal Domains

Posted on May 24th, 2021 - By Hiral M. Sanghavi and Sharmistha Majumdar

[ASAP] Baeyer–Villiger Monooxygenases and Their Mechanism of Oxygen Activation: From Microbes to Humans

[ASAP] The m<sup>6</sup>A Consensus Motif Provides a Paradigm of Epitranscriptomic Studies

Posted on May 9th, 2021 - By Kun Wang, Jinying Peng, and Chengqi Yi

[ASAP] Beginning at the End(s): A Latent End-Binding Network at the Host–Pathogen Interface

Posted on May 9th, 2021 - By Matthew Ravalin and Charles S Craik

[ASAP] Structural Basis for the Interactions of the Colibactin Resistance Gene Product ClbS with DNA

Posted on May 3rd, 2021 - By Prabhanshu Tripathi and Steven D. Bruner

[ASAP] The Autocatalytic Cleavage Domain Is Not Required for the Activity of ScpC, a Virulence Protease from <italic toggle=”yes”>Streptococcus pyogenes</italic>: A Structural Insight

[ASAP] Acetylated Ubiquitin Modulates the Catalytic Activity of the E1 Enzyme Uba1

Posted on Apr 12th, 2021 - By Rachel E. Lacoursiere and Gary S. Shaw

[ASAP] First Tandem Repeat of a Potassium Channel <italic toggle=”yes”>KCNN4</italic> Minisatellite Folds into a V-Loop G-Quadruplex Structure

Posted on Apr 11th, 2021 - By Yoanes Maria Vianney and Klaus Weisz

[ASAP] Protein Polymerization as a Novel Targeted Protein Degradation Mechanism

Posted on Mar 23rd, 2021 - By Raphaëlle Berger and Anthony W. Partridge

[ASAP] The Burden Borne by Protein Methyltransferases: Rates and Equilibria of Non-enzymatic Methylation of Amino Acid Side Chains by SAM in Water

Posted on Mar 5th, 2021 - By Charles A. Lewis, Jr. and Richard Wolfenden

[ASAP] Revealing Donor Substrate-Dependent Mechanistic Control on DXPS, an Enzyme in Bacterial Central Metabolism

Posted on Mar 4th, 2021 - By Melanie L. Johnston and Caren L. Freel Meyers

[ASAP] Structural Perturbations of Exon-Skipping Edits within the Dystrophin D20:24 Region

Posted on Mar 3rd, 2021 - By Xin Niu and Nick Menhart

[ASAP] Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin

[ASAP] p53 Is Potentially Regulated by Cyclophilin D in the Triple-Proline Loop of the DNA Binding Domain

[ASAP] The Size and Stability of Infectious Prion Aggregates Fluctuate Dynamically during Cellular Uptake and Disaggregation

Posted on Jan 26th, 2021 - By Daniel Shoup and Suzette A. Priola

[ASAP] Complete Characterization of Polyacyltrehaloses from <italic toggle=”yes”>Mycobacterium tuberculosis</italic> H37Rv Biofilm Cultures by Multiple-Stage Linear Ion-Trap Mass Spectrometry Reveals a New Tetraacyltrehalose Family

Posted on Jan 25th, 2021 - By Georgiana E. Purdy and Fong-Fu Hsu

[ASAP] Structures of LnmK, a Bifunctional Acyltransferase/Decarboxylase, with Substrate Analogues Reveal the Basis for Selectivity and Stereospecificity

[ASAP] Ubiquitin Ligase Activities of WWP1 Germline Variants K740N and N745S

[ASAP] Retardation of Folding Rates of Substrate Proteins in the Nanocage of GroEL

Posted on Jan 19th, 2021 - By Eda Koculi and D. Thirumalai

[ASAP] Optogenetic Analysis of Allosteric Control in Protein Tyrosine Phosphatases

Posted on Jan 15th, 2021 - By Akarawin Hongdusit and Jerome M. Fox

[ASAP] X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10

[ASAP] Prerecognition Diffusion Mechanism of Human DNA Mismatch Repair Proteins along DNA: Msh2-Msh3 versus Msh2-Msh6

Posted on Dec 15th, 2020 - By Arumay Pal, Harry M. Greenblatt, and Yaakov Levy

[ASAP] Pulse EPR Spectroscopic Characterization of the S<sub>3</sub> State of the Oxygen-Evolving Complex of Photosystem II Isolated from <italic toggle=”yes”>Synechocystis</italic>

[ASAP] In Vitro Hydrolysis of Zinc Chlorophyllide <italic toggle=”yes”>a</italic> Homologues by a BciC Enzyme

[ASAP] Correction to “Hepatocellular Carcinoma and Statins”

[ASAP] The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2<italic toggle=”yes”>R</italic>)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis

Posted on Oct 22nd, 2020 - By Jeremy R. Lohman and Ben Shen

[ASAP] Delineating Heme-Mediated versus Direct Protein Oxidation in Peroxidase-Activated Cytochrome <italic toggle=”yes”>c</italic> by Top-Down Mass Spectrometry

[ASAP] Hidden Conformational States and Strange Temperature Optima in Enzyme Catalysis

Posted on Sep 24th, 2020 - By Johan Åqvist, Jaka Sočan, and Miha Purg

[ASAP] Significance of Individual Domains of ClpL: A Novel Chaperone from <italic toggle=”yes”>Streptococcus mutans</italic>

Posted on Aug 18th, 2020 - By Biswanath Jana† and Indranil Biswas*

[ASAP] Residue-Specific Binding Mechanisms of Thioflavin T to a Surface of Flat ß-Sheets within a Peptide Self-Assembly Mimic

Posted on Jun 9th, 2020 - By pthomas2

[ASAP] Intermolecular and Intramolecular Interactions of the <italic toggle=”yes”>Arabidopsis</italic> Plasma Membrane Proton Pump Revealed Using a Mass Spectrometry Cleavable Cross-Linker

[ASAP] Enzymatic Synthesis of a Fluorogenic Reporter Substrate and the Development of a High-Throughput Assay for Fucosyltransferase VIII Provide a Toolkit to Probe and Inhibit Core Fucosylation

Posted on May 31st, 2020 - By Maxim Soroko† and David H. Kwan*†‡

[ASAP] RNA G-Quadruplexes Facilitate RNA Accumulation in G-Rich Repeat Expansions

Posted on Apr 23rd, 2020 - By pthomas2

[ASAP] A Novel Cryo-EM Structure Enables Development of Selective Cannabinoid Receptor Drugs

Posted on Apr 22nd, 2020 - By Gregory Zilberg† and Daniel Wacker*‡

[ASAP] Allosteric Control of Enzyme Activity: From Ancient Origins to Recent Gene-Editing Technologies

[ASAP] The Endoplasmic Reticulum Regulates Membraneless Organelles through Contact Sites

Posted on Apr 22nd, 2020 - By Shoken Lee and Shirin Bahmanyar*

[ASAP] Determinants of Enantiospecificity in Limonene Synthases

[ASAP] Parsing Molecules for Drug Discovery

[ASAP] Dimerization of Human Drebrin-like Protein Governs Its Biological Activity

[ASAP] Big Insights into Small RNAs

Posted on Apr 13th, 2020 - By Olivia S. Rissland*

[ASAP] Examining the Mechanism of Phosphite Dehydrogenase with Quantum Mechanical/Molecular Mechanical Free Energy Simulations

Posted on Feb 14th, 2020 - By David R. Stevens and Sharon Hammes-Schiffer*

[ASAP] Depurination of Colibactin-Derived Interstrand Cross-Links

[ASAP] Substitutions of Amino Acid Residues in the Substrate Binding Site of Horse Liver Alcohol Dehydrogenase Have Small Effects on the Structures but Significantly Affect Catalysis of Hydrogen Transfer

Posted on Feb 10th, 2020 - By Keehyuk Kim† and Bryce V. Plapp*

[ASAP] Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q<sub>10</sub> Cooperatively Suppress Ferroptosis

Posted on Jan 31st, 2020 - By Kamyar Hadian*

[ASAP] Avian MRP126 Restricts Microbial Growth through Ca(II)-Dependent Zn(II) Sequestration

Posted on Jan 21st, 2020 - By Aaron T. Bozzi and Elizabeth M. Nolan*

[ASAP] Early Metastable Assembly during the Stress-Induced Formation of Worm-like Amyloid Fibrils of Nucleic Acid Binding Domains of TDP-43

[ASAP] Molecular Dynamics Simulations of the Hypoxia-Inducible Factor PAS-B Domain Confirm That Internally Bound Water Molecules Function To Stabilize the Protein Core for Ligand Binding

Posted on Jan 6th, 2020 - By Andrew S. Chong and Peter C. Anderson*

[ASAP] Evolution of Substrates and Components of the Pro/N-Degron Pathway

[ASAP] Determination of a Structural Ensemble Representing the Dynamics of a G-Quadruplex DNA

Posted on Dec 23rd, 2019 - By pthomas2

[ASAP] Correction to “Orchestration of Enzymatic Processing by Thiazole/Oxazole-Modified Microcin Dehydrogenases”

[ASAP] Coupling Computational and Intracellular Screening and Selection Toward Co-compatible cJun and cFos Antagonists

Posted on Dec 19th, 2019 - By pthomas2

[ASAP] Harnessing Human Neural Networks for Protein Design

Posted on Dec 13th, 2019 - By Po-Ssu Huang* and Kirsten A. Thompson

[ASAP] Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase from <italic toggle=”yes”>Leishmania major</italic>

Posted on Nov 27th, 2019 - By pthomas2

[ASAP] Measurement of Net Rate Constants from Enzyme Progress Curves without Curve Fitting

Posted on Nov 22nd, 2019 - By Mark W. Ruszczycky*† and Hung-wen Liu†‡

[ASAP] Single-Cell CRISPR-Based Lineage Tracing in Mice

Posted on Nov 15th, 2019 - By Kian Kalhor† and George M. Church*‡

[ASAP] The Expanding Role of Methyl-Coenzyme M Reductase in the Anaerobic Functionalization of Alkanes

[ASAP] Not All Quiet on the Sugar Front: Glycan Combatants in Host–Pathogen Interactions

Posted on Oct 6th, 2019 - By Atossa C. Ghorashi and Jennifer J. Kohler*

[ASAP] A Transient Intermediate Populated in Prion Folding Leads to Domain Swapping

Posted on Sep 26th, 2019 - By Balaka Mondal and Govardhan Reddy*

[ASAP] Decoding Principles of Selective GPCR-Ga Coupling

Posted on Sep 25th, 2019 - By Sang Min Lim*

[ASAP] Anti-CD3 Antibody for the Prevention of Type 1 Diabetes: A Story of Perseverance

Posted on Sep 23rd, 2019 - By Jason Gaglia†‡ and Stephan Kissler*†‡

[ASAP] Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates

Posted on Sep 13th, 2019 - By pthomas2

[ASAP] Replication of the Enzymatic Temperature Dependency of the Primary Hydride Kinetic Isotope Effects in Solution: Caused by the Protein-Controlled Rigidity of the Donor–Acceptor Centers?

[ASAP] Biosynthesis of GDP-<sc>d</sc>-<italic toggle=”yes”>glycero</italic>-a-<sc>d</sc>-<italic toggle=”yes”>manno</italic>-heptose for the Capsular Polysaccharide of <italic toggle=”yes”>Campylobacter jejuni</italic>

Posted on Aug 28th, 2019 - By Jamison P. Huddleston and Frank M. Raushel*

[ASAP] Functional Characterization of YdjH, a Sugar Kinase of Unknown Specificity in <italic toggle=”yes”>Escherichia coli</italic> K12

Posted on Jul 23rd, 2019 - By Jamison P. Huddleston and Frank M. Raushel*

[ASAP] Effects of Refolding on Large-Scale RNA Structure

Posted on Jul 2nd, 2019 - By Elizabeth A. Dethoff and Kevin M. Weeks*

[ASAP] Helical Behavior of the Interdomain Linker of the <italic toggle=”yes”>Escherichia coli</italic> AraC Protein

Posted on Jun 21st, 2019 - By Matthew J. Brown and Robert Schleif*

[ASAP] <italic toggle=”yes”>Vibrio natriegens</italic>: An Alternative Expression System for the High-Yield Production of Isotopically Labeled Proteins

[ASAP] Design of a Protein Motif Responsive to Tyrosine Nitration and an Encoded Turn-Off Sensor of Tyrosine Nitration

Posted on Jun 11th, 2019 - By Andrew R. Urmey and Neal J. Zondlo*

[ASAP] Characterization of Acyl Carrier Protein-Dependent Glycosyltransferase in Mitomycin C Biosynthesis

Posted on Jun 11th, 2019 - By Hai P. Nguyen† and Kenichi Yokoyama*†‡

[ASAP] Thermally versus Chemically Denatured Protein States

[ASAP] An Intermediate Conformational State of Cytochrome P450cam-CN in Complex with Putidaredoxin

[ASAP] Thrombin Exosite Maturation and Ligand Binding at ABE II Help Stabilize PAR-Binding Competent Conformation at ABE I

Posted on Feb 11th, 2019 - By Ramya Billur, T. Michael Sabo, Muriel C. Maurer

[ASAP] Cas14: Big Advances from Small CRISPR Proteins

Posted on Feb 11th, 2019 - By David F. Savage

[ASAP] Shaping the Future of Protein Engineering

Posted on Feb 6th, 2019 - By Dominic J. Glover, Dawei Xu, Douglas S. Clark

[ASAP] Retro Styles for Vesicle Coats

Posted on Jan 17th, 2019 - By James H. Hurley, Ludger Johannes

[ASAP] Targeting Type 1 Diabetes: Selective Approaches for New Therapies

[ASAP] Effector-Binding-Directed Dimerization and Dynamic Communication between Allosteric Sites of Ribonucleotide Reductase

Posted on Jan 8th, 2019 - By Bill Pham, Richard J. Lindsay, Tongye Shen

[ASAP] Tuning Protein Diffusivity with Membrane Tethers

Posted on Dec 24th, 2018 - By David Mörsdorf, Patrick Müller

[ASAP] The Polycystin Complex Reveals Its Complexity

Posted on Dec 12th, 2018 - By Valeria Padovano, Michael J. Caplan

[ASAP] Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells

Posted on Dec 12th, 2018 - By Brodie L. Ranzau, Alexis C. Komor

[ASAP] Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

[ASAP] Endoplasmic Reticulum–Endosome Contact Sites: Specialized Interfaces for Orchestrating Endosomal Tubule Fission?

Posted on Nov 30th, 2018 - By James L. Daly, Peter J. Cullen

[ASAP] Investigation of Human Neutrophil Elastase Inhibition by <italic toggle=”yes”>Staphylococcus aureus</italic> EapH1: The Key Role Played by Arginine 89

Posted on Nov 30th, 2018 - By Timothy J. Herdendorf, Brian V. Geisbrecht

[ASAP] Ancient Family of Retinal Proteins Brought to Light “Sight-Unseen”

Posted on Nov 30th, 2018 - By Thomas P. Sakmar, Thomas Huber

[ASAP] Discovery and Characterization of a Naturally Occurring, Turn-On Yellow Fluorescent Protein Sensor for Chloride

Posted on Nov 21st, 2018 - By Jasmine N. Tutol, Weicheng Peng, Sheel C. Dodani

[ASAP] Understanding and Engineering Distributed Biochemical Pathways in Microbial Communities

[ASAP] Hinge–Linker Elements in the AAA+ Protein Unfoldase ClpX Mediate Intersubunit Communication, Assembly, and Mechanical Activity

Posted on Nov 20th, 2018 - By Tristan A. Bell, Tania A. Baker, Robert T. Sauer

[ASAP] Binding Affinity and Function of the Extremely Disordered Protein Complex Containing Human Linker Histone H1.0 and Its Chaperone ProTa

Posted on Nov 19th, 2018 - By Hanqiao Feng, Bing-Rui Zhou, Yawen Bai

[ASAP] In Situ Photoregulation of Carbonic Anhydrase Activity Using Azobenzenesulfonamides

[ASAP] Instantaneous Iodine-Assisted DNAzyme Cleavage of Phosphorothioate RNA

Posted on Oct 14th, 2018 - By Po-Jung Jimmy Huang, Woohyun J. Moon, Juewen Liu

[ASAP] High-Throughput Explorations of RNA Structural Modularity

Posted on Oct 14th, 2018 - By Mark A. Boerneke, Kevin M. Weeks