[ASAP] Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules

[ASAP] HDAC6 Substrate Discovery Using Proteomics-Based Substrate Trapping: HDAC6 Deacetylates PRMT5 to Influence Methyltransferase Activity

[ASAP] <italic toggle=”yes”>In Vitro</italic> Reconstitution of the Pantothenic Acid Degradation Pathway in <italic toggle=”yes”>Ochrobactrum anthropi</italic>

[ASAP] Near-Infrared Fluorescent Probes for the Detection of Cancer-Associated Proteases

Posted on Jul 26th, 2021 - By Jamie I. Scott, Qinyi Deng, and Marc Vendrell

[ASAP] Acyl Donor Stringency and Dehydroaminoacyl Intermediates in β-Lactam Formation by a Non-ribosomal Peptide Synthetase

Posted on Apr 12th, 2021 - By Darcie H. Long and Craig A. Townsend

[ASAP] Targeting G-quadruplex Forming Sequences with Cas9

Posted on Mar 25th, 2021 - By Hamza Balci, Viktorija Globyte, and Chirlmin Joo

[ASAP] Natural Occurrence of Hybrid Polyketides from Two Distinct Biosynthetic Pathways in <italic toggle=”yes”>Streptomyces pactum</italic>

Posted on Feb 8th, 2021 - By Wei Zhou, Priyapan Posri, and Taifo Mahmud

[ASAP] Strategies and Tactics for the Development of Selective Glycan-Binding Proteins

[ASAP] Prenylation and Dehydrogenation of a <italic toggle=”yes”>C</italic>2-Reversely Prenylated Diketopiperazine as a Branching Point in the Biosynthesis of Echinulin Family Alkaloids in <italic toggle=”yes”>Aspergillus ruber</italic>

Posted on Dec 31st, 2020 - By Jonas Nies and Shu-Ming Li

[ASAP] Nucleosome Dynamics during Transcription Elongation

[ASAP] Structure Activity Relationship Study of the XIP Quorum Sensing Pheromone in <italic toggle=”yes”>Streptococcus mutans</italic> Reveal Inhibitors of the Competence Regulon

Posted on Oct 1st, 2020 - By Chowdhury Raihan Bikash and Yftah Tal-Gan

[ASAP] Modulation of Bacterial Quorum Sensing by Strigolactones

Posted on Aug 5th, 2020 - By Chen Mozes† and Michael M. Meijler*†

[ASAP] Imaginary Ribozymes

Posted on Aug 2nd, 2020 - By Ronald R. Breaker*

[ASAP] Photo-SNAP-tag, a Light-Regulated Chemical Labeling System

Posted on Jul 15th, 2020 - By Joseph D. Cleveland and Chandra L. Tucker*

[ASAP] <italic toggle=”yes”>In Vitro</italic> Evolution Reveals a Single Mutation as Sole Source of Src-Family Kinase C-Helix-out Inhibitor Resistance

[ASAP] Physicochemical Tools for Visualizing and Quantifying Cell-Generated Forces

Posted on Jun 25th, 2020 - By Ashley K. Nguyen and Kristopher A. Kilian*

[ASAP] The O-GlcNAc Modification on Kinases

Posted on Mar 9th, 2020 - By Paul A. Schwein and Christina M. Woo*

[ASAP] Splice Modulation Synergizes Cell Cycle Inhibition

[ASAP] Chemoenzymatic Semisynthesis of Phosphorylated a-Synuclein Enables Identification of a Bidirectional Effect on Fibril Formation

[ASAP] A Multimodal Ca(II) Responsive Near IR-MR Contrast Agent Exhibiting High Cellular Uptake

[ASAP] Discovery of a Small Molecule Probe of Rpn-6, an Essential Subunit of the 26S Proteasome

Posted on Jan 10th, 2020 - By Wenzhi Tian and Darci J. Trader*

[ASAP] Differential Post-Translational Amino Acid Isomerization Found among Neuropeptides in <italic toggle=”yes”>Aplysia californica</italic>

[ASAP] Discovery of Influenza Polymerase PA–PB1 Interaction Inhibitors Using an <italic toggle=”yes”>In Vitro</italic> Split-Luciferase Complementation-Based Assay

Posted on Nov 21st, 2019 - By Jiantao Zhang, Yanmei Hu, Nan Wu, and Jun Wang*

[ASAP] A Point of Inflection and Reflection on Systems Chemical Biology

[ASAP] Proteolytic Control of Lipid Metabolism

[ASAP] Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential

[ASAP] Sensor I Regulated ATPase Activity of FleQ Is Essential for Motility to Biofilm Transition in <italic toggle=”yes”>Pseudomonas aeruginosa</italic>

[ASAP] Secondary Forces in Protein Folding

[ASAP] Interaction vs Preorganization in Enzyme Catalysis. A Dispute That Calls for Resolution

Posted on Jun 18th, 2019 - By Fredric M. Menger*† and Faruk Nome‡

[ASAP] Single-Molecule Localization Microscopy with the Fluorescence-Activating and Absorption-Shifting Tag (FAST) System

[ASAP] Transient Kinetics Reveal Mechanism and Voltage Dependence of Inhibitor and Substrate Binding to Glutamate Transporters

[ASAP] Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

[ASAP] Transferrin Cycle and Clinical Roles of Citrate and Ascorbate in Improved Iron Metabolism

Posted on Apr 23rd, 2019 - By Aviva Levina, Peter A. Lay

[ASAP] Cytotoxic and Mutagenic Properties of C1′ and C3′-Epimeric Lesions of 2′-Deoxyribonucleosides in Human Cells

[ASAP] How Protein Binding Sensitizes the Nucleosome to Histone H3K56 Acetylation

Posted on Feb 22nd, 2019 - By Jaehyoun Lee, Tae-Hee Lee

[ASAP] Chemical Diversification Based on Substrate Promiscuity of a Standalone Adenylation Domain in a Reconstituted NRPS System

Posted on Feb 4th, 2019 - By Mengyi Zhu, Lijuan Wang, Jing He

[ASAP] Metabolic Regulation of the Epitranscriptome

[ASAP] <italic toggle=”yes”>N</italic>-Acyl <sc>l</sc>-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in <italic toggle=”yes”>Pseudomonas aeruginosa</italic>

[ASAP] Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the <italic toggle=”yes”>Myxococcus fulvus</italic> Secondary Metabolome

Posted on Jan 2nd, 2019 - By Fabian Panter, Daniel Krug, Rolf Müller

[ASAP] Response to “Selective PKCd Inhibitor B106 Elicits Uveal Melanoma Growth Inhibitory Effects Independent of Activated PKC Isoforms”

Posted on Dec 21st, 2018 - By Douglas V. Faller

[ASAP] Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype

Posted on Oct 29th, 2018 - By Yue Li, Matthew D. Disney

[ASAP] A Nonheme Fe<sup>II</sup>/2-Oxoglutarate-Dependent Oxygenase Catalyzes a Double Bond Migration within a Dimethylallyl Moiety Accompanied by Hydroxylation

[ASAP] Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides

[ASAP] Molecular Basis for Autocatalytic Backbone <italic toggle=”yes”>N</italic>-Methylation in RiPP Natural Product Biosynthesis

Posted on Sep 24th, 2018 - By Chayanid Ongpipattanakul, Satish K. Nair

[ASAP] Chemical Proteomics and Super-resolution Imaging Reveal That Chloroquine Interacts with <italic toggle=”yes”>Plasmodium falciparum</italic> Multidrug Resistance-Associated Protein and Lipids

[ASAP] Targeting Fluorescent Sensors to Endoplasmic Reticulum Membranes Enables Detection of Peroxynitrite During Cellular Phagocytosis

[ASAP] Human Milk Oligosaccharides (HMOs) Sensitize Group B <italic toggle=”yes”>Streptococcus</italic> to Clindamycin, Erythromycin, Gentamicin, and Minocycline on a Strain Specific Basis

[ASAP] Discovery of a Nitric Oxide Responsive Quorum Sensing Circuit in <italic toggle=”yes”>Vibrio cholerae</italic>

[ASAP] Optical Recording of Zn<sup>2+</sup> Dynamics in the Mitochondrial Matrix and Intermembrane Space with the GZnP2 Sensor

[ASAP] ICBS 2017 in Shanghai—Illuminating Life with Chemical Innovation

Posted on May 1st, 2018 - By Qi Zhang, Jingyu Zhang, Evripidis Gavathiotis

[ASAP] Neuronal Calcium Recording with an Engineered TEV Protease

Posted on May 1st, 2018 - By Brianna K. O’Neill, Scott T. Laughlin

[ASAP] Protein Acylation Affects the Artificial Biosynthetic Pathway for Pinosylvin Production in Engineered <italic toggle=”yes”>E. coli</italic>

[ASAP] A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance

Photophysical Tuning of N-Oxide-Based Probes Enables Ratiometric Photoacoustic Imaging of Tumor Hypoxia

More Than a Light Switch: Engineering Unconventional Fluorescent Configurations for Biological Sensing

Posted on Feb 20th, 2018 - By William J. Peveler and W. Russ Algar

Understanding the Molecular Mechanisms of the CRISPR Toolbox Using Single Molecule Approaches

Posted on Feb 9th, 2018 - By Digvijay Singh and Taekjip Ha

Development of Activity-Based Chemical Probes for Human Sirtuins

Toward a Microparticle-Based System for Pooled Assays of Small Molecules in Cellular Contexts

Identifying Novel Enhancer Elements with CRISPR-Based Screens

Next-Generation DNA-Functionalized Quantum Dots as Biological Sensors

Posted on Jan 4th, 2018 - By Ganglin Wang, Zhi Li and Nan Ma

Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017Utility and Limitations

Posted on Dec 26th, 2017 - By Jonathan B. Baell and J. Willem M. Nissink

Fluorescent Probes of DNA Repair

Posted on Nov 30th, 2017 - By David L. Wilson and Eric T. Kool

Incorporation of β-Amino Acids Enhances the Antifungal Activity and Selectivity of the Helical Antimicrobial Peptide Aurein 1.2

Repair of a Site-Specific DNA Cleavage: Old-School Lessons for Cas9-Mediated Gene Editing

Posted on Nov 14th, 2017 - By Danielle N. Gallagher and James E. Haber

Large Scale Mutational and Kinetic Analysis of a Self-Hydrolyzing Deoxyribozyme

CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine

Posted on Oct 24th, 2017 - By Martin Kampmann

Ionic Strength Sensing in Living Cells

Posted on Sep 6th, 2017 - By Boqun Liu, Bert Poolman and Arnold J. Boersma

Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8

Posted on Aug 30th, 2017 - By Nicholas J. Porter and David W. Christianson

Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae

Streptomyces virginiae PPDC Is a New Type of Phenylpyruvate Decarboxylase Composed of Two Subunits

Posted on Jul 18th, 2017 - By Xiaoshu Xu, Chao Wang, Jun Chen and Sheng Yang

Celiac Disease: Lessons for and from Chemical Biology

Posted on May 22nd, 2017 - By Chaitan Khosla

Hidden Antioxidative Functions of Reduced Nicotinamide Adenine Dinucleotide Coexisting with Hemoglobin

Posted on May 19th, 2017 - By Magohei Yamada and Hiromi Sakai

Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor

Differential Ability of Five DNA Glycosylases to Recognize and Repair Damage on Nucleosomal DNA

Posted on Jan 23rd, 2017 - By Eric D. Olmon and Sarah Delaney

Duration Control of Protein Expression in Vivo by Light-Mediated Reversible Activation of Translation

Posted on Jan 4th, 2017 - By Shinzi Ogasawara

A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation

Posted on Dec 29th, 2016 - By Brittany A. Moser and Aaron P. Esser-Kahn

Temporal Analysis of PP2A Phosphatase Activity During Insulin Stimulation Using a Direct Activity Probe

Host Cell Interactions Are a Significant Barrier to the Clinical Utility of Peptide Antibiotics

Fluorescence-Activated Cell Sorting of Human l-asparaginase Mutant Libraries for Detecting Enzyme Variants with Enhanced Activity

Posted on Aug 1st, 2016 - By Christos S. Karamitros and Manfred Konrad

pH-Dependent DNA Distortion and Repression of Gene Expression by Pectobacterium atrosepticum PecS

Advances in Enzymatic Glycoside Synthesis

Posted on May 26th, 2016 - By Phillip M. Danby and Stephen G. Withers

The Chemical Ecology of Predatory Soil Bacteria

Posted on Apr 14th, 2016 - By Brandon L. Findlay

Chemically Modifying Viruses for Diverse Applications

Posted on Mar 21st, 2016 - By Kritika Mohan and Gregory A. Weiss

Why Nature Chose Selenium

Posted on Mar 21st, 2016 - By Hans J. Reich and Robert J. Hondal

A Stable Pyrophosphoserine Analog for Incorporation into Peptides and Proteins

Posted on Feb 5th, 2016 - By Lisa M. Yates and Dorothea Fiedler

Sirtuins 1 and 2 Are Universal Histone Deacetylases

Posted on Feb 5th, 2016 - By Willie W. Hsu, Bo Wu and Wenshe R. Liu

Probing Chromatin-modifying Enzymes with Chemical Tools

Posted on Feb 4th, 2016 - By Wolfgang Fischle and Dirk Schwarzer

Protein Arginine Methylation and Citrullination in Epigenetic Regulation

Posted on Dec 31st, 2015 - By Jakob Fuhrmann and Paul R. Thompson

Human Telomere G-Quadruplexes with Five Repeats Accommodate 8-Oxo-7,8-dihydroguanine by Looping out the DNA Damage

Posted on Dec 29th, 2015 - By Na An, Aaron M. Fleming and Cynthia J. Burrows

Boronic Acid for the Traceless Delivery of Proteins into Cells

Posted on Dec 15th, 2015 - By pthomas2

Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR

Posted on Dec 14th, 2015 - By pthomas2

Three Residues Make an Evolutionary Switch for Folding and RNA-Destabilizing Activity in the TTP Family of Proteins

Posted on Dec 14th, 2015 - By Laura M. Deveau and Francesca Massi

Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo

Posted on Dec 14th, 2015 - By pthomas2

Thiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second Residue

Posted on Dec 14th, 2015 - By Feifei Zhang, Chaoxuan Li and Wendy L. Kelly

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

Posted on Dec 10th, 2015 - By pthomas2

Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities

Posted on Dec 9th, 2015 - By pthomas2

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

Posted on Dec 8th, 2015 - By pthomas2

In Vivo Detection of Mitochondrial Dysfunction Induced by Clinical Drugs and Disease-Associated Genes Using a Novel Dye ZMJ214 in Zebrafish

Posted on Dec 8th, 2015 - By pthomas2

Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma

Posted on Dec 7th, 2015 - By Jessica L. Childs-Disney and Matthew D. Disney

Reading between the Lines: “ADD”-ing Histone and DNA Methylation Marks toward a New Epigenetic “Sum”

Posted on Dec 7th, 2015 - By Kyung-Min Noh, C. David Allis and Haitao Li