Drugging viral factories

August 23rd, 2021 by Majda Bratovič

Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00872-w

Drugging viral factories

Put another ring on it

August 23rd, 2021 by Caitlin Deane

Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00871-x

Put another ring on it

Go with the FLOE

August 23rd, 2021 by Ross Cloney

Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00869-5

Go with the FLOE

Ditching the chaperone

August 23rd, 2021 by Grant Miura

Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00870-y

Ditching the chaperone

Bifunctional small molecules that mediate the degradation of extracellular proteins

August 19th, 2021 by David F. Caianiello

Nature Chemical Biology, Published online: 19 August 2021; doi:10.1038/s41589-021-00851-1

Bifunctional ‘MoDE-A’ molecules, which contain ligands that bind to an extracellular protein and carbohydrate residues that recruit it to the asialoglycoprotein receptor, mediate cellular uptake and lysosomal turnover of target proteins.
  • Posted in Nat Chem Biol, Publications
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Lysosome-targeting chimeras evolve

August 19th, 2021 by Joshiawa Paulk

Nature Chemical Biology, Published online: 19 August 2021; doi:10.1038/s41589-021-00835-1

LYTACs induce selective degradation of extracellular proteins by recruiting them to cellular receptors that mediate delivery to the lysosome. Recent development of GalNAc-LYTACs and MoDE-As targeting the liver-specific ASGPR enables cell-type-restricted lysosomal protein degradation and reveals new LYTAC design principles.

Dan Salah Tawfik (1955–2021)

August 16th, 2021 by Paola Laurino

Nature Chemical Biology, Published online: 16 August 2021; doi:10.1038/s41589-021-00864-w

Dan Tawfik suddenly left us on 4 May, 2021. His scientific intuition led him to articulate, and solve, many key questions related to protein chemistry and molecular evolution. Although science, particularly for his students, postdoctoral fellows and colleagues, is dimmer after his loss, his legacy will persist.

Structures and function of the amino acid polymerase cyanophycin synthetase

August 12th, 2021 by Itai Sharon

Nature Chemical Biology, Published online: 12 August 2021; doi:10.1038/s41589-021-00854-y

Structures of three cyanophycin synthetases reveal how the constituent glutathione synthetase and muramyl ligase-like domains cooperate to make cyanophycin, a poly-aspartate chain with arginine residues attached to the sidechains by isopeptide bonds.
  • Posted in Nat Chem Biol, Publications
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Addendum: Cryptic phosphorylation in nucleoside natural product biosynthesis

August 11th, 2021 by Matthew M. Draelos

Nature Chemical Biology, Published online: 11 August 2021; doi:10.1038/s41589-021-00867-7

Addendum: Cryptic phosphorylation in nucleoside natural product biosynthesis
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Accelerated RNA detection using tandem CRISPR nucleases

August 5th, 2021 by Tina Y. Liu

Nature Chemical Biology, Published online: 05 August 2021; doi:10.1038/s41589-021-00842-2

Deploying two unrelated CRISPR nucleases in tandem, with multiplexed CRISPR RNAs and a chemically stabilized activator, creates a simple, one-step assay that can rapidly detect attomolar concentrations of RNA without needing target amplification.