Drugging viral factories
August 23rd, 2021 by Majda Bratovič
Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00872-w
Drugging viral factoriesPut another ring on it
August 23rd, 2021 by Caitlin Deane
Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00871-x
Put another ring on itGo with the FLOE
August 23rd, 2021 by Ross Cloney
Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00869-5
Go with the FLOEDitching the chaperone
August 23rd, 2021 by Grant Miura
Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00870-y
Ditching the chaperoneBifunctional small molecules that mediate the degradation of extracellular proteins
August 19th, 2021 by David F. Caianiello
Nature Chemical Biology, Published online: 19 August 2021; doi:10.1038/s41589-021-00851-1
Bifunctional ‘MoDE-A’ molecules, which contain ligands that bind to an extracellular protein and carbohydrate residues that recruit it to the asialoglycoprotein receptor, mediate cellular uptake and lysosomal turnover of target proteins.Lysosome-targeting chimeras evolve
August 19th, 2021 by Joshiawa Paulk
Nature Chemical Biology, Published online: 19 August 2021; doi:10.1038/s41589-021-00835-1
LYTACs induce selective degradation of extracellular proteins by recruiting them to cellular receptors that mediate delivery to the lysosome. Recent development of GalNAc-LYTACs and MoDE-As targeting the liver-specific ASGPR enables cell-type-restricted lysosomal protein degradation and reveals new LYTAC design principles.Dan Salah Tawfik (1955–2021)
August 16th, 2021 by Paola Laurino
Nature Chemical Biology, Published online: 16 August 2021; doi:10.1038/s41589-021-00864-w
Dan Tawfik suddenly left us on 4 May, 2021. His scientific intuition led him to articulate, and solve, many key questions related to protein chemistry and molecular evolution. Although science, particularly for his students, postdoctoral fellows and colleagues, is dimmer after his loss, his legacy will persist.Structures and function of the amino acid polymerase cyanophycin synthetase
August 12th, 2021 by Itai Sharon
Nature Chemical Biology, Published online: 12 August 2021; doi:10.1038/s41589-021-00854-y
Structures of three cyanophycin synthetases reveal how the constituent glutathione synthetase and muramyl ligase-like domains cooperate to make cyanophycin, a poly-aspartate chain with arginine residues attached to the sidechains by isopeptide bonds.Addendum: Cryptic phosphorylation in nucleoside natural product biosynthesis
August 11th, 2021 by Matthew M. Draelos
Nature Chemical Biology, Published online: 11 August 2021; doi:10.1038/s41589-021-00867-7
Addendum: Cryptic phosphorylation in nucleoside natural product biosynthesisAccelerated RNA detection using tandem CRISPR nucleases
August 5th, 2021 by Tina Y. Liu
Nature Chemical Biology, Published online: 05 August 2021; doi:10.1038/s41589-021-00842-2
Deploying two unrelated CRISPR nucleases in tandem, with multiplexed CRISPR RNAs and a chemically stabilized activator, creates a simple, one-step assay that can rapidly detect attomolar concentrations of RNA without needing target amplification.