Ditching the chaperone
August 23rd, 2021 by Grant Miura
Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00870-y
Ditching the chaperoneDrugging viral factories
August 23rd, 2021 by Majda Bratovič
Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00872-w
Drugging viral factoriesPut another ring on it
August 23rd, 2021 by Caitlin Deane
Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00871-x
Put another ring on itGo with the FLOE
August 23rd, 2021 by Ross Cloney
Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00869-5
Go with the FLOE[ASAP] Uncoupling Amphipathicity and Hydrophobicity: Role of Charge Clustering in Membrane Interactions of Cationic Antimicrobial Peptides
August 22nd, 2021 by Shelley He, Tracy A. Stone, and Charles M. Deber
[ASAP] High-Titer Production of Olivetolic Acid and Analogs in Engineered Fungal Host Using a Nonplant Biosynthetic Pathway
August 19th, 2021 by Ikechukwu C. Okorafor, Mengbin Chen, and Yi Tang
Bifunctional small molecules that mediate the degradation of extracellular proteins
August 19th, 2021 by David F. Caianiello
Nature Chemical Biology, Published online: 19 August 2021; doi:10.1038/s41589-021-00851-1
Bifunctional ‘MoDE-A’ molecules, which contain ligands that bind to an extracellular protein and carbohydrate residues that recruit it to the asialoglycoprotein receptor, mediate cellular uptake and lysosomal turnover of target proteins.Lysosome-targeting chimeras evolve
August 19th, 2021 by Joshiawa Paulk
Nature Chemical Biology, Published online: 19 August 2021; doi:10.1038/s41589-021-00835-1
LYTACs induce selective degradation of extracellular proteins by recruiting them to cellular receptors that mediate delivery to the lysosome. Recent development of GalNAc-LYTACs and MoDE-As targeting the liver-specific ASGPR enables cell-type-restricted lysosomal protein degradation and reveals new LYTAC design principles.[ASAP] Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules
August 18th, 2021 by Adam D. Cotton, James A. Wells, and Ian B. Seiple
Dan Salah Tawfik (1955–2021)
August 16th, 2021 by Paola Laurino
Nature Chemical Biology, Published online: 16 August 2021; doi:10.1038/s41589-021-00864-w
Dan Tawfik suddenly left us on 4 May, 2021. His scientific intuition led him to articulate, and solve, many key questions related to protein chemistry and molecular evolution. Although science, particularly for his students, postdoctoral fellows and colleagues, is dimmer after his loss, his legacy will persist.