Go with the FLOE

August 23rd, 2021 by Ross Cloney

Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00869-5

Go with the FLOE

Ditching the chaperone

August 23rd, 2021 by Grant Miura

Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00870-y

Ditching the chaperone

Drugging viral factories

August 23rd, 2021 by Majda Bratovič

Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00872-w

Drugging viral factories

Put another ring on it

August 23rd, 2021 by Caitlin Deane

Nature Chemical Biology, Published online: 23 August 2021; doi:10.1038/s41589-021-00871-x

Put another ring on it

[ASAP] Uncoupling Amphipathicity and Hydrophobicity: Role of Charge Clustering in Membrane Interactions of Cationic Antimicrobial Peptides

August 22nd, 2021 by Shelley He, Tracy A. Stone, and Charles M. Deber

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Biochemistry
DOI: 10.1021/acs.biochem.1c00367

August 2021 Newsletter Released!

August 19th, 2021 by pthomas2

The August 2021 newsletter was just released. BIOL members should have received it in their email. You can find the newsletter here.

  • Posted in DBC News
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[ASAP] High-Titer Production of Olivetolic Acid and Analogs in Engineered Fungal Host Using a Nonplant Biosynthetic Pathway

August 19th, 2021 by Ikechukwu C. Okorafor, Mengbin Chen, and Yi Tang

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ACS Synthetic Biology
DOI: 10.1021/acssynbio.1c00309
  • Posted in ACS Synthetic Biology, Publications
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Lysosome-targeting chimeras evolve

August 19th, 2021 by Joshiawa Paulk

Nature Chemical Biology, Published online: 19 August 2021; doi:10.1038/s41589-021-00835-1

LYTACs induce selective degradation of extracellular proteins by recruiting them to cellular receptors that mediate delivery to the lysosome. Recent development of GalNAc-LYTACs and MoDE-As targeting the liver-specific ASGPR enables cell-type-restricted lysosomal protein degradation and reveals new LYTAC design principles.

Bifunctional small molecules that mediate the degradation of extracellular proteins

August 19th, 2021 by David F. Caianiello

Nature Chemical Biology, Published online: 19 August 2021; doi:10.1038/s41589-021-00851-1

Bifunctional ‘MoDE-A’ molecules, which contain ligands that bind to an extracellular protein and carbohydrate residues that recruit it to the asialoglycoprotein receptor, mediate cellular uptake and lysosomal turnover of target proteins.
  • Posted in Nat Chem Biol, Publications
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[ASAP] Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules

August 18th, 2021 by Adam D. Cotton, James A. Wells, and Ian B. Seiple

TOC Graphic

ACS Chemical Biology
DOI: 10.1021/acschembio.1c00252