Cryo-EM structure of the RNA-guided ribonuclease Cas12g

January 25th, 2021 by Zhuang Li

Nature Chemical Biology, Published online: 25 January 2021; doi:10.1038/s41589-020-00721-2

The cryo-EM structures of Cas12g in complex with sgRNA in the absence and presence of target RNA reveal that the duplex formed by target RNA and crRNA binds to a central channel of Cas12g, inducing its conformational change and activation.