Reply to: Binding site for MDL-801 on SIRT6
March 1st, 2021 by Zhimin Huang
Nature Chemical Biology, Published online: 01 March 2021; doi:10.1038/s41589-021-00750-5
Reply to: Binding site for MDL-801 on SIRT6Identification of a cellularly active SIRT6 allosteric activator
October 29th, 2018 by Zhimin Huang
Identification of a cellularly active SIRT6 allosteric activator
Identification of a cellularly active SIRT6 allosteric activator, Published online: 29 October 2018; doi:10.1038/s41589-018-0150-0
The use of an allosteric drug-design method resulted in the identification of a first-in-class cellularly active SIRT6 activator that induces cell-cycle arrest in the G0–G1 phase, thus suppressing proliferation in human hepatocellular carcinoma cells.