Ribozymes: How RNA catalyzes cyclization

September 28th, 2015 by Zhensheng Zhong

Nature Chemical Biology 11, 830 (2015). doi:10.1038/nchembio.1928

Authors: Zhensheng Zhong & Gang Chen

The long-awaited crystal structure of the Varkud satellite (VS) ribozyme dimer provides atomic-level insights into how the VS ribozyme folds and catalyzes RNA circularization during rolling circle replication, as well as revealing convergent evolution used by RNAs to catalyze an SN2 reaction.