Kinase inhibitors: An allosteric add-on

September 7th, 2014 by Zachariah H Foda

Nature Chemical Biology 10, 796 (2014). doi:10.1038/nchembio.1630

Authors: Zachariah H Foda & Markus A Seeliger

Development of highly specific kinase inhibitors has been a long-standing challenge in chemical biology. The structural and mechanistic characterization of an Erk1/2 kinase inhibitor provides new strategies to develop specific kinase inhibitors by targeting a binding pocket adjacent to the ATP binding site.