Biosynthesis: A carbonate architect emerges

May 18th, 2014 by Yuhui Sun

Nature Chemical Biology 10, 486 (2014). doi:10.1038/nchembio.1531

Author: Yuhui Sun

Carbonates are known to exist in natural products, but their biosynthesis has not been linked to any enzymes. An unusual fungal Baeyer-Villiger monooxygenase CcsB is now revealed to catalyze an in-line carbonate formation via a two-step mechanism of oxygen atom insertions.