A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance

January 25th, 2021 by Yuan Liu

Nature Chemical Biology, Published online: 25 January 2021; doi:10.1038/s41589-020-00723-0

E3 ligase subunit protein Fbxo48 interacts with phosphorylated Ampkα and mediates its proteasomal degradation. Interruption of the pAmpkα/Fbxo48 interaction by a small-molecule BC1618 promoted Ampkα activation and improved insulin sensitivity.
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