Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation
August 19th, 2019 by Young-Chan Kim
Nature Chemical Biology, Published online: 19 August 2019; doi:10.1038/s41589-019-0344-0
Inhibition of fatty acid synthase, FASN, blocks innate immune signaling through TLR/MyD88 in neutrophils by blocking palmitoylation of MyD88 by palmitoyltransferase zDHHC6 and improves outcomes in two mouse models of sepsis.