Expanding the terpenoid kingdom
November 14th, 2018 by Yongjin J. Zhou
Expanding the terpenoid kingdom
Expanding the terpenoid kingdom, Published online: 14 November 2018; doi:10.1038/s41589-018-0167-4
Terpenoids are assembled from five-carbon (C5) units, which limits the available scaffold chemical space for the discovery of bioactive molecules. A combination of enzyme and metabolic engineering now enables biosynthesis of a plethora of non-natural C11 terpenoids.