Engineering nonphosphorylative metabolism to generate lignocellulose-derived products
February 8th, 2016 by Yi-Shu Tai
Nature Chemical Biology 12, 247 (2016). doi:10.1038/nchembio.2020
Authors: Yi-Shu Tai, Mingyong Xiong, Pooja Jambunathan, Jingyu Wang, Jilong Wang, Cole Stapleton & Kechun Zhang
Enzyme pathways: C1 metabolism redesigned
May 15th, 2015 by Yi-Shu Tai
Nature Chemical Biology 11, 384 (2015). doi:10.1038/nchembio.1819
Authors: Yi-Shu Tai & Kechun Zhang
One-carbon metabolic pathways create new opportunities for metabolic engineering, but natural pathways have limitations in catalytic efficiency and interspecies transferability. Now a computationally designed enzyme, formolase, enables the construction of a synthetic metabolic pathway in Escherichia coli for assimilation of formate into a glycolytic intermediate in only five reaction steps.