Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer
October 30th, 2017 by Yi Qu
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer, Published online: 30 October 2017; doi:10.1038/nchembio.2510
NatureArticleSnippet(type=short-summary, markup=The small molecule nitazoxanide (NTZ) was identified as a Wnt inhibitor by promoting protein citrullination of β-catenin through increased cytosolic calcium and PAD2 protein stabilization. β-catenin citrullination results in proteasomal degradation.