Chemical genetics: Unraveling cell death mysteries

June 17th, 2016 by Xiomaris M Cotto-Rios

Nature Chemical Biology 12, 470 (2016). doi:10.1038/nchembio.2110

Authors: Xiomaris M Cotto-Rios & Evripidis Gavathiotis

Non-apoptotic regulated cell death is not fully characterized, particularly for ferroptosis, the iron- and ROS-dependent form of regulated cell death. A systematic approach using modulatory profiling and cell line sensitivity analysis has unraveled the association of lipid metabolism with ferroptosis and enabled the discovery of a novel specific ferroptosis inducer.