Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking
October 29th, 2018 by Xin Li
Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking
Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking, Published online: 29 October 2018; doi:10.1038/s41589-018-0144-y
An inhibitor of the YEATS domain was developed by targeting a unique π-π-π stacking in the YEATS–Kcr recognition. An ENL YEATS-selective inhibitor, XL-13m, helps probe the YEATS-dependent role of ENL in the leukemogenic transcription program.