Prospecting for molecular glues

August 3rd, 2020 by Willem den Besten

Nature Chemical Biology, Published online: 03 August 2020; doi:10.1038/s41589-020-0620-z

Two recent studies identified CDK12 inhibitors that bind to CDK12–cyclin K complexes and act as molecular glues to stabilize an interaction with the ubiquitin ligase CUL4–DDB1, leading to cyclin K degradation.