Phospholipase iPLA<sub>2</sub>β averts ferroptosis by eliminating a redox lipid death signal

February 4th, 2021 by Wan-Yang Sun

Nature Chemical Biology, Published online: 04 February 2021; doi:10.1038/s41589-020-00734-x

Ca2+-independent phospholipase A2β cleaves an oxidized form of phosphatidylethanolamine (PE) involved in ferroptosis such that increases in PE sensitize cells to ferroptosis. A mutant allele of the enzyme links neurodegeneration and ferroptosis.
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