Protein Design: Getting to the bottom of the TIM barrel

December 17th, 2015 by Vikas Nanda

Nature Chemical Biology 12, 2 (2016). doi:10.1038/nchembio.1987

Author: Vikas Nanda

Natural (βα)8-barrel proteins support diverse catalytic functions and are fertile scaffolds for engineering synthetic enzymes. The atomic-resolution structure determination of a computationally guided, de novo–designed symmetric barrel is a long-awaited advance that opens up new opportunities for enzyme design.