Allosteric mechanism for site-specific ubiquitination of FANCD2

December 23rd, 2019 by Viduth K. Chaugule

Nature Chemical Biology, Published online: 23 December 2019; doi:10.1038/s41589-019-0426-z

UBE2T adopts an allosteric activation mechanism to mediate site-specific ubiquitination of Fanconi anemia complex. Interaction with FANCL induces a cascade of conformational changes of UBE2T and leads to exposure of substrate-binding sites.