Biosynthesis: A terminal triple bond toolbox
December 22nd, 2014 by Victoria S Haritos
Nature Chemical Biology 11, 98 (2015). doi:10.1038/nchembio.1731
Author: Victoria S Haritos
Terminal triple bonds feature in natural products, but their biosynthesis is little known. Now a terminal acetylenase has been characterized for substrate specificity for the first time, and an application to 'bio-click' chemistry has been shown by incorporation of the moiety into natural product scaffolds.