ANXious for YAP

March 15th, 2021 by Toshiro Moroishi

Nature Chemical Biology, Published online: 15 March 2021; doi:10.1038/s41589-021-00766-x

YAP is a major downstream effector of the Hippo intracellular signaling pathway, with key roles in organ development, regeneration, and cancer biology. A small molecule that targets Annexin (ANX) acts through YAP to promote rapid epidermal tissue expansion.