Designing a chemical inhibitor for the AAA protein spastin using active site mutations
February 18th, 2019 by Tommaso Cupido
Designing a chemical inhibitor for the AAA protein spastin using active site mutations
Designing a chemical inhibitor for the AAA protein spastin using active site mutations, Published online: 18 February 2019; doi:10.1038/s41589-019-0225-6
The AAA protein spastin is needed for cell division and organelle transport. Testing spastin constructs with engineered mutations resulted in the identification of a chemical probe to analyze spastin-specific functions in cells.