T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability
September 17th, 2018 by Timothy P. Riley
T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability
T cell receptor cross-reactivity expanded by dramatic peptide–MHC adaptability, Published online: 17 September 2018; doi:10.1038/s41589-018-0130-4
Structural analysis shows that cross-reactivity of the T cell receptor DMF5 is governed by adaptability of the peptide antigen, which can undergo TCR-binding-induced frameshifting forcing the peptide C terminus to extend from the MHC-binding groove.