A stop sign for RAS trafficking

April 29th, 2021 by Tian Qiu

Nature Chemical Biology, Published online: 29 April 2021; doi:10.1038/s41589-021-00789-4

N-Ras lipidation cycling is known to regulate its trafficking and function. A new S-depalmitoylation inhibitor induces N-Ras membrane mislocalization, providing insights into N-Ras function and laying the foundation for a new cancer therapeutic strategy.