Structural biology: Full monty of family B GPCRs
July 18th, 2017 by Thue W Schwartz
Nature Chemical Biology 13, 819 (2017). doi:10.1038/nchembio.2438
Authors: Thue W Schwartz & Thomas M Frimurer
New structures of the glucagon-like peptide-1 (GLP-1) and glucagon receptors in complex with peptide and nonpeptide ligands provide a comprehensive, detailed picture of the molecular mechanisms of action of family B GPCRs. This opens the door for true structure-based drug discovery aimed at both novel orthosteric and allosteric subsites of the receptors.