Notch signaling: A sweet strategy
December 12th, 2017 by Tetsuya Okajima
Notch signaling: A sweet strategy
Notch signaling: A sweet strategy, Published online: 12 December 2017; doi:10.1038/nchembio.2532
Glycosylation of Notch receptors regulates ligand-induced Notch signaling, which is essential for normal development in animals. Fucose analogs targeting Notch glycosylation serve as ligand-specific Notch inhibitors and facilitate the understanding of how O-glycan regulates Notch–ligand interactions.