Computation-guided optimization of split protein systems

February 1st, 2021 by Taylor B. Dolberg

Nature Chemical Biology, Published online: 01 February 2021; doi:10.1038/s41589-020-00729-8

A computational design strategy guided by biophysical principles enables engineering of split protein systems to tune their degree of interfacial destabilization, and thus reconstitution propensity, while preserving stability and catalytic activity.