Linking K29-Ub chains to biology

July 8th, 2021 by Sven M. Lange

Nature Chemical Biology, Published online: 08 July 2021; doi:10.1038/s41589-021-00833-3

Different ubiquitin chain types serve as distinct cellular signals. A new synthetic antigen-binding fragment, sAB-K29, specifically recognizes K29-linked diubiquitin and links K29 chains to proteotoxic stress and their accumulation in midbodies during mitosis.