Biosynthesis: SAM cycles up for colibactin

September 19th, 2017 by Steven G Van Lanen

Nature Chemical Biology 13, 1059 (2017). doi:10.1038/nchembio.2479

Author: Steven G Van Lanen

The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.