PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
May 25th, 2020 by Sreekanth Rajan
Nature Chemical Biology, Published online: 25 May 2020; doi:10.1038/s41589-020-0553-6
Prostaglandins PGE1 and PGA1 have neuroprotective effects by enhancing the transcriptional activity of Nurr1 by directly binding to its ligand-binding domain and upregulating their target genes implicated in Parkinson’s disease.