Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs
February 20th, 2020 by Sophie J. Bradley
Nature Chemical Biology, Published online: 20 February 2020; doi:10.1038/s41589-019-0453-9
Use of receptor variants in knock-in mice to dissect phosphorylation-dependent signaling from G protein-dependent signaling mediated by acetylcholine receptor M1 mAChR defines the ability of receptor ligands to modulate anxiety and locomotion behaviors.