Advanced rules of relays

October 16th, 2020 by Sonja Lorenz

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-0632-8

Transfer of ubiquitin onto target proteins requires controlled interplay between E2 conjugating enzymes and E3 ligases. The structure of a trapped E2~Ub/RCR E3 transfer intermediate provides novel insight into the diversity of mechanisms used to fine tune this relay.