G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3
August 10th, 2020 by Signe Mathiasen
Nature Chemical Biology, Published online: 10 August 2020; doi:10.1038/s41589-020-0617-7
Among the adhesion receptor class of GPCRs, which are understudied, the adhesion receptor ADGRL3 can be activated by its own tethered agonist and couples to G protein G12/13 and somewhat to Gq.