Structural equilibrium underlying ligand-dependent activation of β<sub>2</sub>-adrenoreceptor
January 20th, 2020 by Shunsuke Imai
Nature Chemical Biology, Published online: 20 January 2020; doi:10.1038/s41589-019-0457-5
NMR structural analysis of an active state of the β2-adrenergic receptor defines a unique orientation for the intracellular half of TM6, responsible for G-protein binding, including an equilibrium among three conformations of a key microswitch.