Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation
October 28th, 2019 by Shuai Wang
Nature Chemical Biology, Published online: 28 October 2019; doi:10.1038/s41589-019-0379-2
Small molecules that achieve selective PARP1 degradation were developed that block both the catalytic activity and scaffolding effects of PARP1, enabling the decoupling of PARP1 inhibition and PARP1 trapping.