The case of the missing allosteric ribozymes

January 25th, 2021 by Shanker S. S. Panchapakesan

Nature Chemical Biology, Published online: 25 January 2021; doi:10.1038/s41589-020-00713-2

This Perspective summarizes the known types of ligand-controlled ribozymes and riboswitches and discusses the reasons why allosteric ribozymes formed by fusion of RNA enzymes and RNA aptamers are rare in today’s biological systems.