Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development
December 2nd, 2019 by Semi Lim
Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0415-2
The cellular stability of an oncogenic factor, AIMP2-DX2, is increased via association with HSP70. Interference with this interaction by a small-molecule compound promotes ubiquitin-mediated degradation of AIMP2-DX2 and reduces cancer cell growth.