Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis
March 12th, 2018 by Sean A. Newmister
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis, Published online: 12 March 2018; doi:10.1038/s41589-018-0003-x
The structure of a Stig cyclase, HpiC1, reveals how it catalyzes Cope rearrangement and 6-exo-trig cyclization, including how it controls the position of electrophilic aromatic substation that distinguishes hapalindole from fischerindole alkaloids.