A PCBP1–BolA2 chaperone complex delivers iron for cytosolic [2Fe–2S] cluster assembly
August 12th, 2019 by Sarju J. Patel
Nature Chemical Biology, Published online: 12 August 2019; doi:10.1038/s41589-019-0330-6
The iron chaperone poly(rC)-binding protein 1 (PCBP1) coordinates ferrous iron via its KH3 domain and, together with BolA2 and glutathione, forms a complex that is required for the assembly of [2Fe–2S] clusters on the cytosolic BolA2–Glrx3 chaperone.