Computational redesign of enzymes for regio- and enantioselective hydroamination
May 21st, 2018 by Ruifeng Li
Computational redesign of enzymes for regio- and enantioselective hydroamination
Computational redesign of enzymes for regio- and enantioselective hydroamination, Published online: 21 May 2018; doi:10.1038/s41589-018-0053-0
Computational protein design, without subsequent directed evolution, rapidly provides a set of aspartase variants capable of biocatalytic asymmetric addition of ammonia to substituted acrylates, producing various enantiopure β-amino acids.