Integrated approaches for genome-wide interrogation of the druggable non-olfactory G protein coupled receptor superfamily [Membrane Biology]

June 22nd, 2015 by Roth, B. L., Kroeze, W. K.

G-protein-coupled receptors (GPCRs) are frequent and fruitful targets for drug discovery and development, as well as being off-targets for the side-effects of a variety of medications. Much of the druggable non-olfactory human GPCR-ome remains under-interrogated, and we present here various approaches that we and others have used to shine light into these previously dark corners of the human genome.