Drug-target interactions: Stay tuned

May 25th, 2015 by Robert A Copeland

Nature Chemical Biology 11, 451 (2015). doi:10.1038/nchembio.1831

Author: Robert A Copeland

The ability to vary a drug's residence time on a target is important for drug optimization. A series of reversible covalent inhibitors of select kinases demonstrates the feasibility of tuning residence time from minutes to days through modification of noncovalent features of the molecules.