Expanding the membrane-protein NMR toolkit

July 14th, 2020 by Ricky C. Cheng

Nature Chemical Biology, Published online: 14 July 2020; doi:10.1038/s41589-020-0597-7

An NMR method to monitor conformational states of challenging large protein targets is described. The method, which can be used to evaluate distances between two labels and to measure conformational exchange rates, revealed an unanticipated outward-facing state in a glutamate transporter.