The tail wags the motor

September 9th, 2019 by Richard J. McKenney

Nature Chemical Biology, Published online: 09 September 2019; doi:10.1038/s41589-019-0367-6

Cytoplasmic dynein is a complex molecular motor that steps along microtubules. Advanced biophysical measurements reveal a surprising role for the dynein tail domain in the allosteric control of dynein’s mechanochemistry within assemblies composed of multiple dynein motors.