MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
May 13th, 2019 by Rebecca C. Coll
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Nature Chemical Biology, Published online: 13 May 2019; doi:10.1038/s41589-019-0277-7
MCC950, a small-molecule inhibitor of the NLRP3 inflammasome, interacts directly with NLRP3 at the Walker B motif that hydrolyzes ATP, as defined by a protease-susceptibility assay, mutational analysis, and surface plasmon resonance analysis.