Plasticity in binding confers selectivity in ligand-induced protein degradation
June 11th, 2018 by Radosław P. Nowak
Plasticity in binding confers selectivity in ligand-induced protein degradation
Plasticity in binding confers selectivity in ligand-induced protein degradation, Published online: 11 June 2018; doi:10.1038/s41589-018-0055-y
Selectivity of ligand-induced protein degradation and dimerization is conferred by plastic interprotein contacts. Computational protein–protein docking reveals the underlying interprotein contacts to inform the design of a BRD4 selective degrader.